In the corner I keep 7.5" AR-15 braced pistol with Omega 300 suppressor, Sig MSR RDS, streamlight, and loaded with 110 grain V-Max. Subs will just over penetrate where the V-Max has less of a chance of passing through.
My night stand holds my current EDC pistol, a Beretta Apex Carry with factory installed Vortex RDS. There is a rechargeable handheld flashlight in there as well. 124 gr XTP loads in the mag.
The wife has a Ruger GP100 4.5" .357 Mag ,158 gr HP, in her nightstand with same handheld flashlight. She has several pistols to choose from, she just loves the revolver for simplicity. She carries a .357 Ruger LCR for CCW.